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EGFR-IN-180

CAT: 0804-HY-178824Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178824Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-180 (Compound L15) is an EGFR inhibitor. EGFR-IN-180 shows inhibitory activity against EFGR and EGFR harboring the L858R/T790M/C797S triple drug-resistant mutation, with IC50 values of 80.96 nM and 16.43 nM, reapectively. EGFR-IN-180 can be used for the study of non-small cell lung cancer (NSCLC) [1].
CAS Number
1454651-67-2
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=C(NC2=NC(NC3=CC=C4C(CCCC(C4)N5CCN(CC5)CCO)=C3OC)=NC=C2Cl)C=CC=C1)NC
Molecular Formula
C30H38ClN7O3
Molecular Weight
580.12
References & Citations
[1]Sun Z, et al. Accelerating Scaffold Hopping in Fourth-Generation Epidermal Growth Factor Receptor Inhibitors via Multilevel Virtual Screening. ACS Med Chem Lett. 2025 Sep 30;16 (10) :1927-1934.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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