ML-180

• Product Name Alternative:

  SPDP Crosslinker; Py-ds-Prp-OSu

• UNSPSC Description:

  ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers[1][2].

• Target Antigen:

  Orphan Receptor

• Type:

  Reference compound

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ml-180.html

• Purity:

  99.06

• Solubility:

  DMSO : 11.9 mg/mL (ultrasonic)

• Smiles:

  O=C1N(C2CCCCC2)C(C=C(N3CCN(C4=CC=CC(Cl)=C4)CC3)N1)=O

• Molecular Weight:

  388.89

• References & Citations:

  [1]Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2).|[2]Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87(2):296-304.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  863588-32-3