ML-180

• Description :

  ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM) . ML-180 has the potential for LRH-1-dependent cancers[1][2].

• CAS Number :

  [863588-32-3]

• Product Name Alternative :

  SR1848

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Orphan Nuclear Receptor; Orphan Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ml-180.html

• Purity :

  99.96

• Solubility :

  DMSO : 8.75 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1N(C2CCCCC2)C(C=C(N3CCN(C4=CC=CC(Cl)=C4)CC3)N1)=O

• Molecular Formula :

  C20H25ClN4O2

• Molecular Weight :

  388.89

• Precautions :

  H302

• References & Citations :

  [1]Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2) .|[2]Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87 (2) :296-304.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported