TRPV4-KCa2.3 modulator 1

• Description :

  TRPV4-KCa2.3 modulator 1 (Compound IB-2) is a TRPV4-KCa2.3 protein complex enhancer with antihypertensive activity. TRPV4-KCa2.3 modulator 1 enhances endothelial cell hyperpolarization and vasodilatio. TRPV4-KCa2.3 modulator 1 is promising for research of hypertension and cardiovascular disorders[1].

• UNSPSC :

  12352005

• Target :

  TRP Channel

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Cardiovascular Disease

• Smiles :

  O=C(NCCCCCNC(C1=CC=C(C=C1)F)=O)NC2=CC=C(CN3CCN(CC3)CC)C=C2

• Molecular Formula :

  C26H36FN5O2

• Molecular Weight :

  469.59

• References & Citations :

  [1]Yang S, et al. Design, synthesis, and biological evaluation of TRPV4-KCa2. 3 coupling enhancers as novel therapeutic agents for hypertension[J]. European Journal of Medicinal Chemistry, 2025: 117724.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TRPV4

• CAS Number :

  [2616611-60-8]