KCa2 channel modulator 2

KCa2 channel modulator 2

• CAS Number: 2764618-34-8
• UNSPSC Description: KCa2 channel modulator 2 (compound 2q) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 2 exhibits similar potency on the rat KCa2.2a and human KCa2.3 channel subtypes, with EC50s of 0.64 μM and 0.60 μM, respectively[1]
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/kca2-channel-modulator-2.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC(NC2=C(C=CC(Cl)=C2)F)=NC(N3C(C)=CC(C)=N3)=N1
• Molecular Weight: 331.78
• References & Citations: [1]El-Sayed NS, et al. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022;65(1):303-322.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported