KCa2 channel modulator 1

KCa2 channel modulator 1

• CAS Number: 1019106-73-0
• UNSPSC Description: KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 1 potentiates human KCa2.3 channels with an EC50 value of 0.19 μM and 0.99 μM on the rat KCa2.2 channel subtype[1].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/kca2-channel-modulator-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC(NC2=CC=C(F)C(Cl)=C2)=NC(N3N=C(C)C=C3C)=N1
• Molecular Weight: 331.78
• References & Citations: [1]El-Sayed NS, et al. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022;65(1):303-322.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported