KCa2 channel modulator 1

• Description:

  KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 1 potentiates human KCa2.3 channels with an EC50 value of 0.19 μM and 0.99 μM on the rat KCa2.2 channel subtype[1].

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/kca2-channel-modulator-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC (NC2=CC=C (F) C (Cl) =C2) =NC (N3N=C (C) C=C3C) =N1

• Molecular Formula:

  C16H15ClFN5

• Molecular Weight:

  331.78

• References & Citations:

  [1]El-Sayed NS, et al. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022;65 (1) :303-322.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1019106-73-0