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TRPV4 antagonist 3

CAT: 0804-HY-142620Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142620Size:1 Each
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Description
TRPV4 antagonist 3 is a TRPV4 antagonist (pIC50 = 8.4) .
CAS Number
2681273-35-6
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/trpv4-antagonist-3.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C#N)C=C1C(F)(F)F)(NCC[C@](C)(N)COC2=CC=C(C#N)C(F)=C2)=O
Molecular Formula
C20H18F4N4O3S
Molecular Weight
470.44
References & Citations
[1]Patterson JR, et al. Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions. J Med Chem. 2020 Dec 10;63 (23) :14867-14884.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV4

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