Arrestin-3 modulator-1

• Description :

  Arrestin-3 modulator-1 (Compound LSH-3) is an arrestin-3 modulator. Arrestin-3 modulator-1 binds arrestin-3 at the interdomain interface. Arrestin-3 modulator-1 enhances recruitment of arrestin-3 to phosphorylation-deficient β2AR in cells with increase of FRET levels. Arrestin-3 modulator-1 can be used for congenital disorders like retinal degeneration, hyperthyroidism and obesity research[1].

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor; Arrestin

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Smiles :

  CCN1CCN(C(C(O)=O)C2=CNC3=C2C=CC(NC(C4C(CC=CC4)C(O)=O)=O)=C3)CC1

• Molecular Formula :

  C24H30N4O5

• Molecular Weight :

  454.52

• References & Citations :

  [1]Kurt H, et al. A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor. Commun Chem. 2025 Jul 1;8 (1) :194.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Arrestin-3/β-Arrestin 2; β adrenergic receptor

• CAS Number :

  [1214645-87-0]