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Cyclin K degrader 2

CAT: 0804-HY-177780Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177780Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclin K degrader 2 is a molecular glucose degrading agent that targets the cyclin K protein. Cyclin K degrader 2 has inhibitory activity against CDK1 and CDK9. Cyclin K degrader 2 causes a decrease in RNA polymerase II Ser2 phosphorylation levels, downregulation of DNA damage response gene expression, accumulation of DNA damage, G1 phase arrest of the cell cycle, and apoptosis. Cyclin K degrader 2 can be used for cancer research[1].
UNSPSC
12352005
Target
Apoptosis; CDK; Molecular Glues
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
CN(C1=CC=C(C=C1)CC(NC2=NC=C(S2)SCC3=CC=CN=C3)=O)C
Molecular Formula
C19H20N4OS2
Molecular Weight
384.52
References & Citations
[1]Moison C, et al. DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition. EMBO Rep. 2025 Jun;26 (11) :2836-2854.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK9

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