PROTAC K-Ras Degrader-5

• CAS Number:

  3052745-16-8

• UNSPSC Description:

  pan-KRAS degrader 4 (compound 69) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of [1].

• Target Antigen:

  PROTACs; Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-k-ras-degrader-5.html

• Smiles:

  C#CC1=C(C=CC2=CC(O)=CC(C3=C(C4=NC(OCCN5CCC(CC5)CC6CCN(CC6)CC7CCN(CC7)C8=CC=C9C(N(CC9=C8F)C%10CCC(NC%10=O)=O)=O)=NC(N%11C[C@H]%12N[C@H](CC%12)C%11)=C4C=N3)F)=C21)F

• Molecular Weight:

  1025.17

• References & Citations:

  [1]Jesus Raul Medina. Cereblon-based kras degrading protacs and uses related thereto. US20240287101A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported