PROTAC K-Ras Degrader-3

• Description :

  PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC50 of ≤ 1 nM against SW620 KRAS G12D, and a GI50 of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research[1].

• UNSPSC :

  12352005

• Target :

  PROTACs; Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/protac-k-ras-degrader-3.html

• Purity :

  98.08

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  FC1=C(CC)C2=C(C3=C(F)C4=NC(OCC5(CC5)CN6CCC(CN7CC8(CCN(C9=CC=C(C(N([C@@H]%10C(NC(CC%10)=O)=O)C%11)=O)C%11=C9)CC8)C7)(C)CC6)=NC(N%12C[C@@](O)(C)CCC%12)=C4C=N3)C=C(O)C=C2C=C1

• Molecular Formula :

  C57H67F2N9O6

• Molecular Weight :

  1012.20

• References & Citations :

  [1]Robert L, et al. Glutarimide-containing pan-kras-mutant degrader compounds and uses thereof, WO2024118966A1, 2024-06-06

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  K-Ras

• CAS Number :

  [3043670-68-1]