PROTAC K-Ras Degrader-3

• CAS Number:

  3043670-68-1

• UNSPSC Description:

  PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC50 of ≤ 1 nM against SW620 KRAS G12D, and a GI50 of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research[1].

• Target Antigen:

  PROTACs; Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-k-ras-degrader-3.html

• Smiles:

  FC1=C(CC)C2=C(C3=C(F)C4=NC(OCC5(CC5)CN6CCC(CN7CC8(CCN(C9=CC=C(C(N([C@@H]%10C(NC(CC%10)=O)=O)C%11)=O)C%11=C9)CC8)C7)(C)CC6)=NC(N%12C[C@@](O)(C)CCC%12)=C4C=N3)C=C(O)C=C2C=C1

• Molecular Weight:

  1012.20

• References & Citations:

  [1]Robert L, et al. Glutarimide-containing pan-kras-mutant degrader compounds and uses thereof, WO2024118966A1, 2024-06-06

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported