TD-522

• Description :

  TD-522 is a potent and selective molecular glue GSPT1 degrader, with a DC50 of 0.269 nM. TD-522 exhibits strong anti-proliferative effects and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cells. TD-522 suppresses tumor growth in a TMD-8 xenograft model. TD-522 can be used for AML and DLBCL research[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Molecular Glues

• Related Pathways :

  Apoptosis; PROTAC

• Field of Research :

  Cancer

• Smiles :

  CC(C1=CC=C2N=NN(C(C2=C1)=O)C3CCC(NC3=O)=O)NC(NC4=CC=C(C(Cl)=C4)C(C)(C)C)=O

• Molecular Formula :

  C25H27ClN6O4

• Molecular Weight :

  510.97

• References & Citations :

  [1]Takwale AD, et al. Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model. Bioorg Chem. 2022 Oct;127:105923.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2417647-40-4]