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TD-522

CAT: 0804-HY-177750Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-177750Size:1 Each
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Description
TD-522 is a potent and selective molecular glue GSPT1 degrader, with a DC50 of 0.269 nM. TD-522 exhibits strong anti-proliferative effects and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cells. TD-522 suppresses tumor growth in a TMD-8 xenograft model. TD-522 can be used for AML and DLBCL research[1].
CAS Number
[2417647-40-4]
UNSPSC
12352005
Target
Apoptosis; Molecular Glues
Related Pathways
Apoptosis; PROTAC
Field of Research
Cancer
Smiles
CC(C1=CC=C2N=NN(C(C2=C1)=O)C3CCC(NC3=O)=O)NC(NC4=CC=C(C(Cl)=C4)C(C)(C)C)=O
Molecular Formula
C25H27ClN6O4
Molecular Weight
510.97
References & Citations
[1]Takwale AD, et al. Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model. Bioorg Chem. 2022 Oct;127:105923.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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