TD-522

• Description:

  TD-522 is a potent and selective molecular glue GSPT1 degrader, with a DC50 of 0.269 nM. TD-522 exhibits strong anti-proliferative effects and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cells. TD-522 suppresses tumor growth in a TMD-8 xenograft model. TD-522 can be used for AML and DLBCL research[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Molecular Glues

• Related Pathways:

  Apoptosis; PROTAC

• Field of Research:

  Cancer

• Smiles:

  CC (C1=CC=C2N=NN (C (C2=C1) =O) C3CCC (NC3=O) =O) NC (NC4=CC=C (C (Cl) =C4) C (C) (C) C) =O

• Molecular Formula:

  C25H27ClN6O4

• Molecular Weight:

  510.97

• References & Citations:

  [1]Takwale AD, et al. Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model. Bioorg Chem. 2022 Oct;127:105923.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2417647-40-4