GL-522

• Description :

  GL-522 (4-Sulfocalix[8]arene) is a Aβ42 inhibitor. GL-522 bind to Aβ42 through nonspecific and multipoint hydrophobic interactions with a Kd of 276 μM. GL-522 effectively inhibits Aβ42 fibrillation and reduces amyloid cytotoxicity. GL-522 can be used for Alzheimer's disease research[1].

• Product Name Alternative :

  4-Sulfocalix[8]arene

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Amyloid-β

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=S(O)(C1=CC(CC2=CC(S(=O)(O)=O)=CC(CC3=CC(S(=O)(O)=O)=CC(CC4=CC(S(=O)(O)=O)=CC(CC5=C(O)C(CC6=C(O)C(CC7=C(O)C(CC8=C(O)C(C9)=CC(S(=O)(O)=O)=C8)=CC(S(=O)(O)=O)=C7)=CC(S(=O)(O)=O)=C6)=CC(S(=O)(O)=O)=C5)=C4O)=C3O)=C2O)=C(O)C9=C1)=O

• Molecular Formula :

  C56H48O32S8

• Molecular Weight :

  1489.48

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Wang Z, et al. para-Sulfonatocalix[n]arenes Inhibit Amyloid β-Peptide Fibrillation and Reduce Amyloid Cytotoxicity. Chem Asian J. 2017 Feb 1;12 (3) :341-346.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• CAS Number :

  [137407-62-6]