TD-0212

• Description :

  TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

• UNSPSC :

  12352005

• Target :

  Angiotensin Receptor; Neprilysin

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/TD-0212.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C1=CC=CC=C1C2=CC=C(CN3C(CNC([C@H](CC(C)C)S)=O)=C(CC)N=C3OCC)C(F)=C2)=O

• Molecular Formula :

  C28H34FN3O4S

• Molecular Weight :

  527.65

• References & Citations :

  [1]McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI) . ACS Med Chem Lett. 2018 Dec 3;10 (1) :86-91.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AT1 Receptor

• CAS Number :

  [1073549-10-6]