TD-0212

• Description:

  TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

• UNSPSC:

  12352005

• Target:

  Angiotensin Receptor; Neprilysin

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/TD-0212.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC (C1=CC=CC=C1C2=CC=C (CN3C (CNC ([C@H] (CC (C) C) S) =O) =C (CC) N=C3OCC) C (F) =C2) =O

• Molecular Formula:

  C28H34FN3O4S

• Molecular Weight:

  527.65

• References & Citations:

  [1]McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI) . ACS Med Chem Lett. 2018 Dec 3;10 (1) :86-91.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AT1 Receptor

• CAS Number:

  1073549-10-6