TD-165

• Description :

  TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  PROTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/td-165.html

• Purity :

  98.08

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

• Molecular Formula :

  C46H59N7O8S

• Molecular Weight :

  870.07

• Precautions :

  H315, H319

• References & Citations :

  [1]Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9 (1) :19654.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [2305936-56-3]