TD-165

• Description:

  TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/td-165.html

• Purity:

  98.08

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

• Molecular Formula:

  C46H59N7O8S

• Molecular Weight:

  870.07

• Precautions:

  H315, H319

• References & Citations:

  [1]Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9 (1) :19654.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  [2305936-56-3]