TD-6301

• Description :

  TD-6301 is a bladder-selective M2/4 muscarinic receptor antagonist. TD-6301 binds to and blocks M2/4 muscarinic receptors with high selectivity, especially human M2 receptors with strong affinity (Ki = 0.36 nM) . TD-6301 inhibits volume-induced bladder contractions (ID50 = 0.075 mg/kg) . TD-6301 can be used in the research of overactive bladder[1].

• UNSPSC :

  12352005

• Target :

  MAChR

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Endocrinology

• Smiles :

  NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3CN(CC3)CCCCCCCN(C4CCN(CC4)CC5=CN=CC=C5OC)C(C)C)=O

• Molecular Formula :

  C40H57N5O2

• Molecular Weight :

  639.91

• References & Citations :

  [1]McNamara A, et al. Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist. Eur J Pharmacol. 2009 Mar 1;605 (1-3) :145-52.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [690999-15-6]