TD-428

CAT: 0804-HY-114407-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114407-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TD-428 is a PROTAC connected by ligands for Cereblon and BRD4. TD-428 is a highly specific BRD4 degrader with a DC50 of 0.32 nM[1]. TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor) . TD-428 efficiently induce BET protein degradation[1].
CAS Number
[2334525-50-5]
Product Name Alternative
BE-34776
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TD-428.html
Purity
98.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(OCCOCCOCCNC2=C3C(N=NN(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)=CC=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5
Molecular Formula
C43H43ClN10O7S
Molecular Weight
879.38
References & Citations
[1]Kim SA, et al. A novel cereblon modulator for targeted protein degradation. Eur J Med Chem. 2019 Mar 15;166:65-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; Cereblon

Related Products

CatalogName
HY-130714-01TD-165
HY-114412TD-0212
HY-117620TD-6450
HY-19942TD-5471
HY-177750TD-522
HY-146397TD-802
HY-114406-01TD-106
HY-P2482TD-1
HY-171843TD-6301
HY-15642-01TD-198946

Alternative Products

CatalogName
T13105-01TD-428
MBS3607490-01TD-198946
M27017-01TD-165
T13104TD-106
B2266-5TD-139
M10302-01TD-0212
T202103-01TD-004
T203006-01TD-3
T74520-01TD-802
T207120-01TD-5471

Popular Products