PNR-3-82

CAT: 0804-HY-176836Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176836Size:1 Each
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Description
PNR-3-82 is a selective Apoptotic endonuclease G (EndoG) inhibitor with an IC50 of 0.61 μM for EndoG over DNase I. PNR-3-82 does not inhibit five cell death-related enzymes including DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-82 has a cytoprotective activity and blocks Cisplatin (HY-17394) and Docetaxel (HY-B0011) -induced cell death. PNR-3-82 can be used for cell injuries research[1].
CAS Number
[1424353-64-9]
UNSPSC
12352005
Target
Endonuclease
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(OC)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S
Molecular Formula
C25H17N3O4S
Molecular Weight
455.49
References & Citations
[1]Jang DS, et al. Novel cytoprotective inhibitors for apoptotic endonuclease G. DNA Cell Biol. 2015 Feb;34 (2) :92-100.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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