DI-82

• Description:

  DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity[1].

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/di-82.html

• Purity:

  98.0

• Solubility:

  DMSO : 120 mg/mL (ultrasonic)

• Smiles:

  NC1=NC (S[C@H] (C) C (N=C2C (C=C3OCCNS (=O) (C) =O) =CC=C3OC) =C (S2) C) =NC (N) =C1

• Molecular Formula:

  C20H26N6O4S3

• Molecular Weight:

  510.65

• References & Citations:

  [1]Julian Nomme, et al. Structure-guided Development of Deoxycytidine Kinase Inhibitors With Nanomolar Affinity and Improved Metabolic Stability. J Med Chem. 2014 Nov 26;57 (22) :9480-94.|[2]Helena Almqvist, et al. CETSA Screening Identifies Known and Novel Thymidylate Synthase Inhibitors and Slow Intracellular Activation of 5-fluorouracil. Nat Commun. 2016 Mar 24;7:11040.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1638148-50-1