AChE-IN-82

• Description :

  AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2[1].

• UNSPSC :

  12352005

• Target :

  Beta-secretase; Cholinesterase (ChE) ; COX; LOX-1; Monoamine Oxidase

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  COC1=C(O)C=CC(/C=C/C(NC2=CC(N=C(NCN3C(SCC3=O)=O)S4)=C4C=C2)=O)=C1

• Molecular Formula :

  C21H18N4O5S2

• Molecular Weight :

  470.52

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE; BACE1; BChE; COX-1; COX-2; MAO-A; MAO-B