AChE-IN-82

• Description:

  AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2[1].

• UNSPSC:

  12352005

• Target:

  Beta-secretase; Cholinesterase (ChE) ; COX; LOX-1; Monoamine Oxidase

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  COC1=C (O) C=CC (/C=C/C (NC2=CC (N=C (NCN3C (SCC3=O) =O) S4) =C4C=C2) =O) =C1

• Molecular Formula:

  C21H18N4O5S2

• Molecular Weight:

  470.52

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; BACE1; BChE; COX-1; COX-2; MAO-A; MAO-B