AChE-IN-82

CAT: 0804-HY-170938Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-170938Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2[1].
UNSPSC
12352005
Target
Beta-secretase; Cholinesterase (ChE) ; COX; LOX-1; Monoamine Oxidase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
COC1=C(O)C=CC(/C=C/C(NC2=CC(N=C(NCN3C(SCC3=O)=O)S4)=C4C=C2)=O)=C1
Molecular Formula
C21H18N4O5S2
Molecular Weight
470.52
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BACE1; BChE; COX-1; COX-2; MAO-A; MAO-B

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