PNR-3-80

CAT: 0804-HY-176835-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-176835-01Size:5 mg
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Description
PNR-3-80 is a selective Apoptotic endonuclease G (EndoG) inhibitor with an IC50 of 0.67 μM for EndoG over DNase I. PNR-3-80 does not have inhibitory activities for DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-80 has a potent cytoprotective activity, and it significantly protects human prostate carcinoma cells from Cisplatin (HY-17394) and Docetaxel (HY-B0011) -induced cell death and represses Etoposide (HY-13629) -induced DNA damage and autophagy. PNR-3-80 can be used for cell injuries research[1][2].
CAS Number
[1424353-63-8]
UNSPSC
12352005
Target
Endonuclease
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(Cl)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S
Molecular Formula
C24H14ClN3O3S
Molecular Weight
459.90
References & Citations
[1]Wang W, et al. Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nat Commun. 2021 Jan 20;12 (1) :476. |[2]Jang DS, et al. Novel cytoprotective inhibitors for apoptotic endonuclease G. DNA Cell Biol. 2015 Feb;34 (2) :92-100.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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