CCL-34

• Description:

  CCL-34 is a Toll-like receptor 4 (TLR4) activator. CCL-34 significantly induced dendritic cell (DC) CD83 expression and IL-12p70 production in a dose-dependent manner, thereby inducing DC maturation. CCL-34 enhanced the allostimulatory activity of DC on naive CD4+CD45+RA+ T cell proliferation and IFN-γ secretion. CCL-34 further induced antigen presentation ability in mice inoculated with doxorubicin-treated colorectal cancer cells. CCL-34 can be used in studies of immune stimulation.

• UNSPSC:

  12352211

• Target:

  Toll-like Receptor (TLR)

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CCCCCCCCCCCNC([C@@H](NC(CCCCCCCCCCC)=O)CO[C@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CO)=O

• Molecular Formula:

  C32H62N2O8

• Molecular Weight:

  602.84

• References & Citations:

  [1]Fu SL, et al. CCL-34, a synthetic toll-like receptor 4 activator, modulates differentiation and maturation of myeloid dendritic cells. Oncotarget. 2016 Mar 8;7 (10) :11677-86.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TLR4

• CAS Number:

  [943316-60-7]