CCL-34

• Target:

  TLR

• Related Pathways:

  Immunology/Inflammation

• Bioactivity:

  CCL-34 is an activator of Toll-like receptor 4 (TLR4) . It significantly induces the expression of CD83 on dendritic cells (DC) and the production of IL-12p70 in a dose-dependent manner, thereby promoting DC maturation. CCL-34 enhances the allostimulatory activity of DC on the proliferation of naive CD4+CD45+RA+ T cells and their secretion of IFN-?. Furthermore, CCL-34 can enhance antigen presentation capability in mice inoculated with doxorubicin-treated colorectal cancer cells. CCL-34 is applicable for research in immune stimulation.

• Smiles:

  O(C[C@@H](C(NCCCCCCCCCCC)=O)NC(CCCCCCCCCCC)=O)[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O

• Molecular Formula:

  C32H62N2O8

• Molecular Weight:

  602.84

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  943316-60-7