CCL-3

CAT: 0209-101-M273Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M273Size:50 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.
Synonyms
CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
NCBI Gene ID
6348
UniProt
P10147
Accession Number
NP_002974
Accession Number mRNA
NM_002983
Chromosomal Location
17q12
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human CCL-3
Clone
(#11F16)
Applications
Detection Ab
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

Related Products

CatalogName
101-M270CCL-26 (Eotaxin-3)
101-M275CCL-7 (MCP-3)
101-M262CCL-19 (MIP-3 beta)
103-M338CCL-9
101-M161CCL-11
103-M320CCL-1
101-M163CCL-15
101-M263CCL-2
103-M326CCL-20 (MIP-3 alpha)
101-M255CCL-1

Alternative Products

CatalogName
HY-176755CCL-34
hAP-0138Human CCL-14
mAP-0180Rat Monoclonal anti-mouse CCL-3
T202794-01CCL-34-S5
216210CCL-3 (Chemokine C-C Motif Ligand 3)
MBS554165-01Mouse MIP-1 alpha (CCL-3) Recombinant
MBS691650-01Rat RANTES (CCL 5)
SEKCN-0169-01Chicken CCL/MCP-1
MBS691610-01Mouse RANTES (CCL 5)
MBS692044-01Human RANTES (CCL 5)

Popular Products