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BTK-IN-34

CAT: 0804-HY-162257Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162257Size:1 Each
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Description
BTK-IN-34 (compound 9h) is a selective BTK inhibitor. BTK-IN-34 shows antiproliferative activity in RAMOS cells through selective inhibition of pBTK (Tyr223) without affecting Lyn and Syk, upstream proteins in the BCR signaling pathway[1].
CAS Number
3016419-52-3
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-in-34.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=C(S(=O)(N3CCN(C(CCCC)=O)CC3)=O)C=C2)/C1=C4CCCC\4
Molecular Formula
C22H29N3O4S
Molecular Weight
431.55
References & Citations
[1]Vani Madhuri Velavalapalli, et al. Novel 5-Substituted Oxindole Derivatives as Bruton’s Tyrosine Kinase Inhibitors: Design, Synthesis, Docking, Molecular Dynamics Simulation, and Biological Evaluation. ACS Omega 2024, 9, 7, 8067-8081.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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