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RIPK1-IN-34

CAT: 0804-HY-178464Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178464Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPK1-IN-34 is a selective, brain-penetrant RIPK1 inhibitor (IC50 = 126.70 nM) with almost no inhibitory effect on RIPK3 (IC50 > 10, 000 nM) . RIPK1-IN-34 offers substantial neuroprotection by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) within the necroptosis pathway. RIPK1-IN-34 shows the neuroprotective effect in a rat middle cerebral artery occlusion (MCAO) model. RIPK1-IN-34 can be used for the study of anti-acute ischemic stroke (AIS) [1].
CAS Number
3065634-19-4
UNSPSC
12352005
Target
Mixed Lineage Kinase; Necroptosis; RIP kinase
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=C2C=C(C3=CC4=NC(NC(C5CC5)=O)=NN4C=C3)C=CC2=NC(C)=N1)N[C@H](C6=CC=CC=C6)C
Molecular Formula
C28H25N7O2
Molecular Weight
491.54
References & Citations
[1]Su R, et al. Design, synthesis, anti-acute ischemic stroke (AIS) effect of receptor-interacting protein kinase 1 (RIPK1) inhibitors containing quinazoline structure. Bioorg Chem. 2025 Oct;165:109013.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1

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