CCL-11

CAT: 0209-101-M161Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M161Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Microsequencing of the purified protein revealed the guinea pig CCL11 to be a member of the beta (CC) chemokine family of inflammatory and immunoregulatory cytokines. cDNA clones for guinea pig, mouse, and human CCL11 have been isolated. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the aminoterminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11. At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11. In addition, human CCL11 also shows high amino acid sequence identity to human MCP1, 2, and 3. Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.
Synonyms
CCL11; SCYA11
NCBI Gene ID
6356
UniProt
P51671
Accession Number
NP_002977.1
Accession Number mRNA
NM_002986.2
Chromosomal Location
17q21.1-q21.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human CCL-11
Clone
(#7D14)
Applications
WB, FC
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

Related Products

CatalogName
103-M338CCL-9
101-M273CCL-3
103-M320CCL-1
101-M163CCL-15
101-M263CCL-2
101-M255CCL-1
103-M337CCL-8
101-M259CCL-16
103-M336CCL-6
101-M274CCL-5

Alternative Products

CatalogName
216181CCL-11 (Chemokine C-C Motif Ligand 11)
hAP-0136AMouse Monoclonal anti-Human CCL-11
EK-033-40Eotaxin / CCL-11 (Mouse) - ELISA Kit
216182CCL-11 (Eotaxin, Chemokine C-C Motif Ligand 11)
hAP-5703Sheep Polyclonal anti-Human CCL-11 (Eotaxin)
mAP-0168Rat Monoclonal anti-mouse CCL-11 (Eotaxin)
HY-176755CCL-34
hAP-0138Human CCL-14
T202794-01CCL-34-S5
MBS691650-01Rat RANTES (CCL 5)

Popular Products