Jingzhaotoxin-34

Jingzhaotoxin-34

• UNSPSC Description: Jingzhaotoxin-34, a 35-residue polypeptide, is a neurotoxin. Jingzhaotoxin-34 inhibits tetrodotoxin-sensitive (TTX-S) sodium currents (IC50 of ~85 nM) while having no significant effects on tetrodotoxin-resistant (TTX-R) sodium currents on rat dorsal root ganglion neurons[1].
• Target Antigen: Sodium Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/jingzhaotoxin-34.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CN)N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(NC(C(N[C@H](C(NC(C(NC(C(N2C(C(N[C@H]3CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(O)=O)CCC5)=O)CO)=O)CC6=CNC7=CC=CC=C67)=O)[C@H](CC)C)=O)=O)CCC2)=O)CCCCN)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CO)=O)CSSC[C@H](NC8=O)C(N[C@H](C(N9[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4CC%10=CNC%11=CC=CC=C%10%11)=O)CCCCN)=O)[C@H](CC)C)=O)C)=O)CCC9)=O)CCC(N)=O)=O)=O)CCC1)=O)CO)=O)CC%12=CNC%13=CC=CC=C%12%13)=O)CCSC)=O)[C@@H](C)O)=O)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]8CO)=O)CC%14=CC=CC=C%14)=O)CC(N)=O)=O)CC(O)=O)=O
• Molecular Weight: 3561.08
• References & Citations: [1]Jinjun Chen, et al. Expression and characterization of jingzhaotoxin-34, a novel neurotoxin from the venom of the tarantula Chilobrachys jingzhao. Peptides. 2009 Jun;30(6):1042-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported