PROTAC CDK2/9 Degrader-1

PROTAC CDK2/9 Degrader-1

• CAS Number: 2408641-24-5
• UNSPSC Description: PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand[1].
• Target Antigen: CDK; PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-cdk2-9-degrader-1.html
• Purity: 99.85
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C(C1=NNC=C1NC2=C3C(NC=C3)=NC=N2)NC4=CC=C(CN5CCN(C(CCC(NCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)=O)CC5)C=C4
• Molecular Weight: 815.84
• References & Citations: [1]Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported