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PDE4-IN-28

CAT: 0804-HY-176234Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176234Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE4-IN-28 (Compound G1) is a PDE4D inhibitor (IC50: 29 nM) . PDE4-IN-28 inhibits the production of TNF-α and NO (IC50: 13.32 and 2.32 μM, respectively) . PDE4-IN-28 exhibits anti-inflammatory, antibacterial and analgesic effects in a rat pressure ulcer (PU) model and promotes HUVEC cell migration, thereby accelerating wound healing[1].
UNSPSC
12352005
Target
Bacterial; NO Synthase; Phosphodiesterase (PDE) ; TNF Receptor
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Smiles
O=C1N(C2=C(C(N1C)=O)N(CCC(NNC(C3=NN4C(C5=CC(OCC6CC6)=C(C=C5)OC(F)F)=CC=NC4=C3)=O)=O)C=N2)C
Molecular Formula
C28H27F2N9O6
Molecular Weight
623.57
References & Citations
[1]Qian X, et al. Design, Synthesis, and Biological Evaluation of New PDE4 Inhibitors for the Treatment of Pressure Ulcers. J Med Chem. 2025 Jun 12;68 (11) :11628-11647.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

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