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Bcl-2-IN-23

CAT: 0931-T211048-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211048-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Bcl-2 Family, Apoptosis, Necroptosis
Related Pathways
Apoptosis
Bioactivity
Bcl-2-IN-23 (compound 5) is a selective inhibitor targeting Bcl-2. It demonstrates an IC50 range of 25.7-33.7 μM in HTB-140, HeLa, and SW620 cells. Acting through non-covalent competitive binding to the Bcl-2 protein, Bcl-2-IN-23 significantly reduces Bcl-2 expression, inducing late-stage apoptosis and necroptosis in cancer cells. By disrupting the Bcl-2-mediated mitochondrial apoptotic inhibition pathway, it increases cancer cell susceptibility to apoptosis and reduces the release of the inflammatory factor IL-6. Bcl-2-IN-23 is applicable in anti-apoptosis research for malignant tumors such as melanoma, cervical cancer, and colorectal cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

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HY-176219Bcl-2-IN-23
221022-01Bcl-2 (Apoptosis Regulator Bcl-2, Bcl 2, BCL2) discontinued
MBS8565489-01BCL-2

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