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JTP-103237

CAT: 0804-HY-135505Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135505Size:1 Each
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Description
JTP-103237 is a MGAT2 inhibitor (IC50: 0.019 μM and 6.423 μM for hMGAT2 and hMGAT3 respectively) . JTP-103237 modulates fat absorption, decreases plasma glucose levels and prevents diet-induced obesity[1].
CAS Number
1883864-16-1
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/jtp-103237.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)OC1=CC=C(C2=NN=C3CN(C4=NC(C(C)(C)C)=CC(C(C)(C)C)=N4)CCN32)C=C1
Molecular Formula
C24H29F3N6O
Molecular Weight
474.52
References & Citations
[1]Okuma C, et al. JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur J Pharmacol. 2015 Jul 5;758:72-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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