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PROTAC EGFR degrader 4

CAT: 0931-T74515-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74515-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2882845-50-1
Target
Others, EGFR, Autophagy, PROTACs
Related Pathways
Angiogenesis, Others, Autophagy, PROTAC, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
PROTAC EGFR degrader 4 is a potent molecule designed to target and degrade mutant EGFR, effectively inducing degradation of EGFR del19 and EGFR L858R/T790M with DC50 values of 0.51 nM and 126 nM, respectively. It significantly inhibits the growth of HCC827 and H1975 cell lines, demonstrating IC50 values of 0.83 nM and 203.1 nM, respectively. The induced degradation of EGFR by this compound is associated with autophagy [1].
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCN2CCN(CC2)c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)C(C)(C)C)cc1
Molecular Formula
C55H70N12O4S
Molecular Weight
995.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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