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PROTAC sEH-degrader-4

CAT: 0804-HY-179166Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179166Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC sEH-degrader-4 is a highly efficient PROTAC degrader that targets soluble epoxide hydrolase (sEH) (pDC50 = 10.3). PROTAC sEH-degrader-4 can be used for research on inflammation-related diseases. Pink: sEH ligand ; Blue: E3 ligase CRBN ligand (HY-179168) ; Black: Linker[1].
UNSPSC
12352005
Target
Epoxide Hydrolase; PROTACs
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Inflammation/Immunology
Smiles
O=C(NCCCC1=CN(CCN2CCN(C3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4=O)=O)C=C3)CC2)N=N1)C6=CC=C(O[C@H]7CC[C@H](NC(NC8=CC=C(OC(F)(F)F)C=C8)=O)CC7)C=C6
Molecular Formula
C45H49F3N10O8
Molecular Weight
914.93
References & Citations
[1]Schönfeld J, et al. Click chemistry enables rapid development of potent sEH PROTACs using a direct-to-biology approach. Chem Commun (Camb) . 2025 Nov 13;61 (92) :18108-18111.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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