Products for Research Use Only
RegisterLogin

ALK degrader 1

CAT: 0804-HY-175849Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-175849Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ALK degrader 1 is a potent, hydrophobic tag (HyT) -based degrader that induces ubiquitin-proteasome system (UPS) -dependent EML4-ALK degradation (DC50 = 0.13 μM) . ALK degrader 1 demonstrates potent ALK degradation and antiproliferative effects in ALK-dependent cell lines, while showing minimal cytotoxicity in ALK fusion-negative cells. ALK degrader 1 triggers cell cycle arrest at the G0/G1 phase and stimulates apoptosis. ALK degrader 1 not only facilitates efficient degradation of the ALK protein but also disrupts key downstream effectors, including the STAT3 signaling axis. ALK degrader 1 mediates robust EML4-ALK degradation in vivo. ALK degrader 1 can be used for ALK-related diseases research[1].
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; PROTACs; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C(C=C(CC)C(N1CCN(CCCC(NC2(C3)C[C@@H](C4)C[C@H]3C[C@@H]4C2)=O)CC1)=C5)=C5C6(C)C)C7=C6NC8=CC(C#N)=CC=C87
Molecular Formula
C39H47N5O2
Molecular Weight
617.82
References & Citations
[1]Zhu J, et al. Development of Adamantane-based hydrophobic tags targeting anaplastic lymphoma kinase with enhanced antitumor activities. Bioorg Chem. 2025 Sep;164:108876.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-175527ALK degrader 2
HY-161750PROTAC ALK degrader-2
HY-168551-01PROTAC ALK degrader-3
HY-179732PROTAC ALK degrader-4
HY-176207HDAC degrader-1
HY-156401BRD9 Degrader-1
HY-151606-01Akt3 degrader 1
HY-168029eEF2K degrader-1
HY-142925ER degrader 1
HY-172882IKZF2-degrader 1

Alternative Products

CatalogName
TBI5001-5MGSTING Degrader 1, STING degrader
T74545-01STAT3 degrader-1
T211896-01GSPT1 degrader-7
T211514-01Lck degrader-1
T210553-01ER degrader 11
T209932-01CDK4 degrader 1
T209911-01BRD4 degrader-2
T209877-01AR Degrader-1
T209376-01Tubulin degrader 1
T207627-01CDK9 degrader-1

Popular Products