PROTAC ALK degrader-2

PROTAC ALK degrader-2

• UNSPSC Description: PROTAC ALK degrader-2 (B1-PEG) is an ALK degrader based on PROTACs, with the DC50 of 45 nM in H3122 EML4-ALK DC50 (GSH+). PROTAC ALK degrader-2, through PEGylation, is engineered to self-organize into micelles in water and releases its active form in response to the tumor-specific high GSH environment[1].
• Target Antigen: Anaplastic lymphoma kinase (ALK); PROTACs
• Type: Reference compound
• Related Pathways: PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-alk-degrader-2.html
• Smiles: CC(C)S(C1=C(NC2=C(Cl)C=NC(NC3=C(OC(C)C)C=C(C4CCN(CC(N(CC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)CCSSCCNC(COCCOCCO)=O)=O)CC4)C(C)=C3)=N2)C=CC=C1)(=O)=O.[n]
• Molecular Weight: 3100 (Approximately)
• References & Citations: [1]Shirui Wang, et al. Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation. J Med Chem. 2024 Jun 27;67(12):9842-9856.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported