RORγ agonist 2

• Description:

  RORγ agonist 2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. RORγ agonist 2 significantly inhibits tumors growth in syngeneic MC38 tumor mice model[1].

• UNSPSC:

  12352005

• Target:

  ROR

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Smiles:

  CCS(=O)(C1CCN(C(C)=O)C(C(NC2=CC(F)=C(C(C(F)(F)F)=C2)OC3=CC(C4CC4)=NC(C5CC5)=C3)=O)C1)=O

• Molecular Formula:

  C28H31F4N3O5S

• Molecular Weight:

  597.62

• References & Citations:

  [1]Fukuda S, et al. A Concise and Modular Approach to Generate Novel RORγ Agonists. J Med Chem. 2025 Jul 18.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  RORα; RORγ