RORγ agonist 1

• Description:

  RORγ agonist 1 is a potent and orally bioavailable RORγ agonist (EC50 = 21 nM) with antitumor activity.

• UNSPSC:

  12352005

• Target:

  ROR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rorγ-agonist-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FCCN1C2=CC=C(C(N[C@H](C3=CC=C(C=C3)S(CC)(=O)=O)CO)=O)C=C2C=C1CC4=C(C=C(C=C4)Cl)C(F)(F)F

• Molecular Formula:

  C29H27ClF4N2O4S

• Molecular Weight:

  611.05

• References & Citations:

  [1]Lu B, et al. Discovery of 2- (Ortho-Substituted Benzyl) -Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity. J Med Chem. 2021 Oct 28;64 (20) :14983-14996.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2260631-91-0]