ROR agonist-1

• Description :

  ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1].

• CAS Number :

  [2361528-74-5]

• UNSPSC :

  12352005

• Target :

  ROR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ror-agonist-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@H](NC(C)=O)C1=CC=C(S(=O)(CC)=O)C=C1)NC2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2

• Molecular Formula :

  C21H20F6N2O5S

• Molecular Weight :

  526.45

• References & Citations :

  [1]von Berg S, et al. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. ACS Med Chem Lett. 2019 May 29;10 (6) :972-977.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported