RORγt agonist 2

• Description:

  RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 promotes the differentiation of Th17 cells and enhances the levels of pro-inflammatory cytokines, thereby increasing the cytotoxicity of lymphocytes. RORγt agonist 2 inhibits the production of regulatory T cells, which suppresses the immune response (extracted from patent WO2021136339A1, compound 17) [1].

• UNSPSC:

  12352005

• Target:

  ROR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/rorγt-agonist-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C1N(C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C(N[C@H](C4=CC=C(C=C4)S(CC)(=O)=O)CC#N)=O)C=C3OC1)C

• Molecular Formula:

  C30H30F3N3O4S

• Molecular Weight:

  585.64

• References & Citations:

  [1]Liu Bin, et al. Amides with bicyclic structures and their applications in pharmaceuticals. Patent WO2021136339A1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2663787-92-4]