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RORγ inverse agonist 2

CAT: 0804-HY-175490Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175490Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RORγ inverse agonist 2 (Compound 15) is a potent inverse agonist of the retinoic acid receptor-related orphan receptor RORγ, with IC50 values of 0.4 and 0.9 μM for Gal4-RORγ and full-length RORγ, respectively. RORγ inverse agonist 2 is useful in the study of autoimmune diseases[1].
CAS Number
1242610-59-8
UNSPSC
12352005
Target
ROR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
CC1(C)C(/C(C[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C)=C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=C\C6=CC=CO6)=O
Molecular Formula
C35H48O4
Molecular Weight
532.75
References & Citations
[1]Schwarz PF, et al. Identification of New Lupane-Type Triterpenoids as Inverse Agonists of RAR-Related Orphan Receptor Gamma (RORγ) . J Nat Prod. 2025 Aug 22;88 (8) :1887-1900.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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