Products for Research Use Only
RegisterLogin

Nrf2-IN-4

CAT: 0804-HY-175209-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-175209-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Nrf2-IN-4 is a Nrf2 inhibitor. Nrf2-IN-4 induces ferroptosis via NRF2 inhibition. Nrf2-IN-4 disrupts cellular iron homeostasis, facilitates ferritin degradation, and ultimately triggers ferroptosis. Nrf2-IN-4 induces lysosome activation by promoting iron-dependent ROS production and lysosomal acidification. Nrf2-IN-4 demonstrates significant antitumor efficacy. Nrf2-IN-4 can be used for the study of breast cancer[1].
CAS Number
2417486-06-5
UNSPSC
12352005
Target
Atg8/LC3; Ferroptosis; Keap1-Nrf2; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=C(Cl)C=C(C2=CSC(N/N=C(C3=CC=CC=N3)/C4=NC=CC=C4)=N2)C=C1
Molecular Formula
C20H13Cl2N5S
Molecular Weight
426.32
References & Citations
[1]Meng X, et al. Discovery of novel thiazolylhydrazone derivatives as potent anti-cancer agents inducing ferroptosis via direct NRF2 inhibition. Eur J Med Chem. 2025 Jun 28;297:117912.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-149508-01Nrf2-IN-3
HY-101025-01Nrf2-IN-1
HY-168922Keap1-Nrf2-IN-25
HY-168161Keap1-Nrf2-IN-23
HY-162096Keap1-Nrf2-IN-17
HY-115849-01Nrf2-Activator-12G
HY-145879-01Nrf2 activator-2
HY-148480Nrf2 activator-6
HY-146168Nrf2 activator-5
HY-156081Nrf2 activator-9

Alternative Products

CatalogName
T211919-01Nrf2-IN-4
BUP21987Nrf2 activator-4
MBS5804472Keap1-Nrf2-IN-4
GTR19274588-01Nrf2-IN-4 hydrobromide
402705-01Nrf2
TBI3573-100MG4-Octyl itaconate, Nrf2 activator
BA8615-1Nrf2-IN-1
70R-50116NRF2 antibody
GWB-423BE6Nrf2, Antibody
344789-01Nrf2 discontinued

Popular Products