Nrf2-IN-4

• Target:

  Nrf2|||ROS|||Ferroptosis|||ATG

• Related Pathways:

  Immunology/Inflammation|||Apoptosis|||Autophagy

• Bioactivity:

  Nrf2-IN-4 is an Nrf2 inhibitor that induces ferroptosis by disrupting cellular iron homeostasis, promoting ferritin degradation, and ultimately triggering ferroptosis. It activates lysosomes through iron-dependent reactive oxygen species (ROS) production and lysosomal acidification. Nrf2-IN-4 demonstrates significant antitumor effects and is applicable in breast cancer research.

• Smiles:

  ClC=1C=CC(=CC1Cl)C=2N=C(SC2)NN=C(C3=NC=CC=C3)C4=NC=CC=C4

• Molecular Formula:

  C20H13Cl2N5S

• Molecular Weight:

  426.32

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2417486-06-5