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PROTAC B-Raf degrader 1

CAT: 0804-HY-111758-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111758-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity[1].
CAS Number
2364367-27-9
UNSPSC
12352005
Target
PROTACs; Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PROTAC_B-Raf_degrader_1.html
Purity
99.78
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CNC(CNC4=CC(CS(=O)(/C=C/C5=C(OC)C=C(OC)C=C5OC)=O)=CC=C4OC)=O
Molecular Formula
C36H37N5O12S
Molecular Weight
763.77
References & Citations
[1]Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Mar 19;87:191-199.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf

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