NF-κB degrader 1

CAT: 0013-GTR19263400-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19263400-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NF-κBdegrader 1 (Compound MD-1) is an NF-κB1p105 subunit degrader. It exhibits anti-inflammatory properties, with an IC50 of 2.02 μM for inhibiting TNF-α and 5.40 μM for inhibiting NO. NF-κBdegrader 1 induces p105 degradation via the Cullin-RING ligase (CRL) SCFBTCP, thereby inhibiting NF-κB transcriptional activity. This compound shows potential for research in inflammation-related diseases.

Field of Research

Signal Transduction

Storage Conditions

-20°C

Notes

For research use only.

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