TLR4/NF-κB-IN-1

TLR4/NF-κB-IN-1

• UNSPSC Description: TLR4/NF-κB-IN-1 (Compound 7x) is an orally available inhibitor that specifically targets the TLR4/NF-κB signaling pathway, offering anti-inflammatory effects and the ability to cross the blood-brain barrier. TLR4/NF-κB-IN-1 can reduce acute neuroinflammation in mice caused by LPS (HY-D1056) and downregulate the expression of TLR4, P-NF-κB and P-IκB-α proteins[1].
• Target Antigen: IKK; NF-κB; Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;NF-κB
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tlr4-nf-κb-in-1.html
• Smiles: FC1=CC=C(CN2C=CC3=C(NC4=CC(NC(N5)=O)=C5C=C4)N=CN=C32)C=C1
• Molecular Weight: 374.37
• References & Citations: [1]Liang Xiong, et al. Design and synthesis of novel derivatives of bisepoxylignans as potent anti-inflammatory agents involves the modulation of the M1/M2 microglia phenotype via TLR4/NF-κB signaling pathway. Eur J Med Chem. 2025 Jan 15:282:117092.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported