PROTAC PARP1 degrader-3

• UNSPSC Description:

  PROTAC PARP1 degrader-3 (Compound C6) is a PROTAC degrader for PARP1 with a DC50 of 58.14 nM. PROTAC PARP1 degrader-3 exhibits cytotoxicity in cancer cell SW-620 and LOVO with IC50 of 1.63 μM and 2.84 μM. PROTAC PARP1 degrader-3 exhibits a synergistic effect with SN-38 (HY-13704) in BRCA-mutated colon cancer cell with a combination index (CI) of 0.487. (Blue: Ligand for E3 ligase Cereblon (HY-23095); Pink: Ligand for target protein (HY-10619); Black: Linker (HY-16872))[1]

• Target Antigen:

  PARP; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-parp1-degrader-3.html

• Smiles:

  NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CN(CCC5CCN(CCC6CCN(CC7CCN(C8=CC9=C(C(N(C%10CCC(NC%10=O)=O)C9=O)=O)C=C8)CC7)CC6)CC5)CCC4)C=C3)N=C21)=O

• Molecular Weight:

  896.13

• References & Citations:

  [1]Wu M, et al., Discovery of a potent PARP1 PROTAC as a chemosensitizer for the treatment of colorectal cancer. Eur J Med Chem. 2025 Jan 15;282:117062.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported