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Antitumor agent-200

CAT: 0804-HY-173182Size: 1 EachDry Ice: NoHazardous: No
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Description
Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor. By binding to the colchicine site of tubulin, it causes G2/M cell cycle arrest and generates reactive oxygen species (ROS) . Antitumor agent-200 exhibits significant inhibitory activity against MCF7/ADR and KBV200 cell lines with overexpression of P-glycoprotein (P-gp), with drug resistance indices (DRI) of 0.83 and 0.58 respectively. In the MCF-7 xenograft model, Antitumor agent-200 (25 mg/kg, intraperitoneal injection) can achieve a tumor growth inhibition rate of 57.2%. Antitumor agent-200 can be used in the research of the anti-cancer field[1].
CAS Number
3046118-64-0
UNSPSC
12352005
Target
Microtubule/Tubulin; P-glycoprotein
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
FC(C=C1C(NCC2=CC=C([Se]C)C(O)=C2)=O)=CC=C1N3CCOCC3
Molecular Formula
C19H21FN2O3Se
Molecular Weight
423.34
References & Citations
[1]Jiang B, et al. Identification of selenium-containing benzamides as potent microtubule-targeting antitumor agents. Bioorg Chem. 2025 Mar 10;159:108355.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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