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PPARα/γ agonist 4

CAT: 0804-HY-162578Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162578Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PPARα/γ agonist 4 (Compound (S) -7) is an orally active dual potent agonist of PPARα and PPARγ, with EC50 values of 0.061 μM and 1.42 μM respectively. PPARα/γ agonist 4 acts through an insulin-independent mechanism and exhibits mitochondrial pyruvate carrier inhibition and anti-diabetic properties. PPARα/γ agonist 4 is expected to be used in research for dyslipidemic type 2 diabetes[1].
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pparα-γ-agonist-4-1.html
Smiles
O=C(O)[C@H](CC1=CC=CC=C1)OC2=CC=C(C=C2)C3=C4C(C=CC=C4)=CC=C3
Molecular Formula
C25H20O3
Molecular Weight
368.42
References & Citations
[1]Laghezza A. A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties. Eur J Med Chem. 2024; 275:116567.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ

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