HDAC-IN-87

• Description:

  HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD50 of greater than 500 mg/kg in male and female rats[1].

• UNSPSC:

  12352005

• Target:

  Fungal; HDAC

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Infection

• Purity:

  99.89

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  FC(C1=NC(C2=CC=C(COC3=NC=NC(C(F)F)=C3)S2)=NO1)(F)F

• Molecular Formula:

  C13H7F5N4O2S

• Molecular Weight:

  378.28

• References & Citations:

  [1]Liu XH, et al. Novel 5- (Trifluoromethyl) -1,2,4-oxadiazole-Based Pyrimidin-4-ether Histone Deacetylase Inhibitors for Controlling Rust Disease: Design, Synthesis, Activity, and Structure-Activity Relationship. J Agric Food Chem. 2025 Feb 26;73 (8) :4563-4573.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3039482-69-1