STAT3-IN-40

• Description :

  STAT3-IN-40 (Compound 8b) is an anti-cancer agent. STAT3-IN-40 can trigger the immune responses of CD4+ and CD8+ T lymphocytes and induce ferroptosis and apoptosis of tumor cells by inhibiting the expression and phosphorylation of STAT3. STAT3-IN-40 can be used in the research of chemoimmunotherapeutic agents for cancer[1].

• CAS Number :

  [3053241-01-0]

• UNSPSC :

  12352005

• Target :

  Apoptosis; Ferroptosis; STAT

• Related Pathways :

  Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  O=C(N1C/C(C(/C(C1)=C/C2=CC=C(C=C2)[N+]([O-])=O)=O)=C\C3=CC=C(C=C3)[N+]([O-])=O)CCCC([O-][Pt+4]45([NH2][C@@]6([H])[C@](CCCC6)([H])[NH2]4)([O-]C(C([O-]5)=O)=O)[Cl-])=O

• Molecular Formula :

  C32H34ClN5O12Pt

• Molecular Weight :

  911.18

• References & Citations :

  [1]Mao ZC, et al. Design, synthesis and evaluation of diarylidenyl piperidone-ligated platinum (IV) complexes as chemoimmunotherapeutic agents. Eur J Med Chem. 2025 Apr 5;287:117338.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported